The Integrated Center for Structure and Function Innovation:
a PSI-2 Specialized Technology Center

Mission Statement

The Integrated Center for Structure and Function Innovation (ISFI) is an NIH Protein Structure Initiative Specialized Center focused on developing and applying a set of synergistic technologies organized to overcome recognized bottlenecks in structure determination at the key steps of production of soluble protein and protein crystallization.

LANL Technology Development University of Virginia LANL Protein Production UCLA LBNL Crystallization and Xray facility LLNL Crystallization Univ of Chicago
Top 10 targets [See all targets]
Rv2430c PPE41 (TB H37Rv) (1)In PDBMichael StrongJan 14th, 2008
Rv2431c PE25 (TB H37Rv) (1)In PDBMichael StrongJan 14th, 2008
Rv1314c (TB H37Rv) (1)In PDBJin Ho MoonJan 14th, 2008
Rv1404 (TB H37Rv) (1)In PDBLi-Wei HungJan 14th, 2008
tbe OMPR-C DNA Binding Protein (Escherichia coli) (1)In PDBUC GroupOct 3rd, 2007
Rv2850c (TB H37Rv) (1)In PDBLi-Wei HungFeb 20th, 2007
APC1446 YPHP (Bacillus subtilis) (1)Crystal StructureDavid CooperApr 23rd, 2008
Rv0223c (TB H37Rv) (2)Crystal StructureJin Ho MoonJan 14th, 2008
APC36150 RBSTP2382 (Bacillus stearothermophilus) (2)Crystal StructureDavid CooperJan 14th, 2008
Rv0626 (TB H37Rv) (1)Diffraction-quality CrystalsLinda MiallauFeb 5th, 2008
Structure Gallery 2IB0 [Slide show PDB]
Number of targets at:
Selected
256
xCloned
205
xxExpressed
119
xxxSoluble
52
xxxxPurified
43
xxxxxCrystallized
28
xxxxxxDiffraction-quality Crystals
16
xxxxxxxDiffraction
14
xxxxxxxxCrystal Structure
10
xxxxxxxxxIn PDB
6


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